Grant of the Government of the Russian Federation for the state support of scientific researches, which are conducted under the guidance of leading scientists in Russian educational institutions of higher professional education (agreement No. 11.G34.31.0065 dated October 19, 2011)

Regeneration of airways and lung

The official website of the project "Investigating the molecular mechanisms and underlying pathways of regenerative medicine approaches the tissue-engineering and cell therapy of airways and lungs"

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On-line Protocol of Trachea Transplantation

Leading scientist – Professor Paolo Macchiarini Leading scientist – Professor Paolo Macchiarini
Kuban State Medical University Kuban State Medical University
Ochapovsky Krasnodar Regional Hospital Ochapovsky Krasnodar Regional Hospital

International Symposium and School of Young Scientists

“Prospects of regenerative medicine for tissue engineering of intrathoracic organs” December 11, 2015

New diaphragms grown from stem cells offer hope of a cure for common birth defect and possibly future repairs of the heart

An international collaboration between scientists in Sweden, Russia, and the United States has resulted in the successful engineering of new diaphragm tissue in rats using a mixture of stem cells and a 3D scaffold. When transplanted, it has regrown with the same complex mechanical properties of diaphragm muscle. The study is published in the journal Biomaterials, and offers hope of a cure for a common birth defect and possible future heart muscle repairs.

Poster Award Nominee

Poster presentation “Tissue engineered lungs in rats and nonhuman primates” by Elena Kuevda, PhD, International Center of Regenerative Medicine KubGMU, was nominated for the Poster Award at the World Conference on Regenerative Medicine (Leipzig, October 21-23, 2015).

Presentation of “Megagrant”

Presentation of “Megagrant” – a documentary novel by Elena Kokurina, was held in the Oval hall of Rudomino All-Russia State Library for Foreign Literature on May 28.

Megagrant is a documentary novel by Elena Kokurina, issued by the publishing house Boslen

The author is a science journalist and a member of the Russian Association of Science Writers and Journalists, having worked on the newspapers Obstchaya gazeta and Moskovskie novosti, and magazines Russki Newsweek and V mire nauki. Her book tells a story in which she herself played a direct part

International Symposium “Regeneration of intrathoracic organs and tissues” conducted in KSMU

It is already the fourth symposium conducted within the Grant ofthe Government of the Russian Federation. As usual,it included the School of young scientists. More than 400 people from the different cities of Russia took part in it this time.

International Symposium and School of Young Scientists

December, 19: International Symposium and School of Young Scientists "Regeneration of Thoracic Organs and Tissues"

The Gold Medal for the heart

Alexander Sotnichenko, post-graduate student of pathological anatomy department, the governmental grant researcher, was awarded the Gold medal “All-Russia Exhibition Center Laureate” on the XIV All-Russia exhibition of research and technological achievements of the young scientists. The exhibition was conducted in All-Russia Exhibition Center in Moscow on June 24-27, 2014

Transplantation of tissue-engineered has been carried out in Krasnodar

June 3, 2014: A patient from Crimea underwent tissue-engineered tracheal transplantation in Krasnodar regional clinical hospital ¹1. Seven years ago the young man was injured in a car accident and since that time underwent 14 surgeries in Ukraine, including Kiev. However, no improvement has been observed.

Tissue engineering has been used to construct natural oesophagi, which in combination with bone marrow stem cells have been safely and effectively transplanted in rats

The study, published in Nature Communications, shows that the transplanted organs remain patent and display regeneration of nerves, muscles, epithelial cells and blood vessels. Alexander Sotnichenko, 26, PhD student of the Kuban State Medical University (Krasnodar, Russia) took part in this study. For the first time Russian researcher becomes co-author in the publication for Nature Com.

Grant Council of the Russian Government made decision on the Project’ extension

Based on the results of international assessment of the results of 2011-2013 and application, submitted by the PI and the Kuban state medical university, Grant Board adopted a resolution of expediency of 2 years prolongation of the project conducted, financed from the Federal budget in amount of 22,5 million rubles in 2014, the amount of co-financing attracted by the University for research is unlimited. Amount of co-financing, attracted by the University for research in 2015, must be not less than 22,5 million rubles.

December 11, 2013: International Symposium and the 4thRegenerative Medicine School for Young Scientists “Organs and Tissues Regeneration” was conducted on the basis of the International Research, Clinical and Educational Center of Regenerative Medicine

Professor Doris Taylor,Regenerative Medicine Research Director of the Texas Heart Institute (USA, Texas), delivered a keynote lecture.

A foreign patient underwent trachea transplantation in Krasnodar

A 42-year-old patient from Jordanian, who underwent a unique tracheal transplantation performed with the use of bioengineered scaffold seeded with patient’s own cells, was dismissed from Krasnodar regional clinical hospital ¹1. According to Hospital press-office, postoperative care lasted for about a month; the patient is doing well now.

Trachea transplant at Children's Hospital of Illinois gives korean toddler new windpipe

Child is first in the world to receive tissue-engineered bioartificial trachea grown with her own cells

First Heart - Lung Decelluarization in Russia

The novel equipment ORCA (Organ Regeneration Collection Analysis) Bioreactor - system specially designed to meet the needs of the regenerative medicine – was installed and started up in the Center of Regenerative Medicine of Kuban state medical university

Center of Regenerative Medicine is opened in Krasnodar

November 7, 2012: Official opening ceremony of the Center of Regenerative Medicine took place at the Kuban State Medical University. Deputy Minister of Healthcare of Russian Federation Igor Kagramanyan opened the lab together with Professor Paolo Macchiarini and Professor Sergey Alekseenko, Chancellor of KSMU

3rd School for young scientists with international participation “Global experience of heart and lungs bioengineering” , November 8, 2012

The school is devoted to the launching of the International research, clinical and educational center of regenerative medicine at the Kuban State Medical University

At the Karolinska Institute in Sweden, rat hearts and lungs are washed of living cells to reveal the extracellular structure

This photo opens the article in the New York Times (16/09/2012) "Organ Tailor-Made With Body's Own Cells", devoted to the work and ideas of Professor Paolo Macchiarini and his lab.

Online questions to Professor Macchiarini

Within two months readers of Journal “Cell Transplantology and Tissue Engineering”, our collaborators, had possibility to ask questions to Professor Paolo Macchiarini online. Results of the "People's interview" we are publishing today

The patients were discharged after first bioartificial stem-cell based laryngo-tracheal transplantation

Two patients were discharged from Krasnodar Clinical Hospital on the 14th of July, 2012, after successful first bioartificial stem-cell based laryngo-tracheal transplantation performed by Paolo Macchiarini, Professor of Regenerative Medicine of Karolinska Institute (Sweden) and Vladimir Porhanov, head of oncological and thoracic department of Kuban State Medical University (Russia).

First bioartificial stem-cell based laryngo-tracheal transplantation

The first bioartificial stem-cell based laryngo-tracheal transplantation was performed on June 19th at the Krasnodar Regional Hospital (Russia) by Paolo MACCHIARINI, professor of regenerative surgery at the Karolinska Institutet (Sweden, Stockholm), and collegues

Preliminary stage of training in Karolinska done

Young specialists from Kuban State Medical University, members of the grant research team, Elena Gubareva and Aleksandr Sotnichenko underwent the first stage of training in the Karolinska Institute (Sweden) in the department of regenerative medicine. They spent there the first two weeks 09.04.2012 – 23.04.2012.

V Annual International Symposium “Topical issues of gene and cellular technologies”

On May 28, 2012 Professor Paolo Macchiarini will participate in the V Annual International Symposium “Topical issues of gene and cellular technologies” in Moscow with the presentation: "Lessons learned from natural and synthetic bioengineered tracheal transplants and implications for future organs"
Here you can find the program of the conference and to register.

International video conference - important step for transplantation

On February 16, 2012 the first international video conference on regenerative medicine headed by the leading scientist professor Paolo Macchiarini took place in Clinical Regional Hospital after prof. Ochapovsky within frames of the grant money of the Government of the Russian Federation. Russian and foreign hospitals took part in this conference: Stokholm – Huston – Krasnodar – Florence – Moscow. Possibilities of bioengineered tracheal transplantation for patients with diseases of upper airways were discussed during this online conference


Regenerative Medicine Breaking News

A tissue sample and a biodegradable scaffold were used to grow vaginas in the right size and shape for each woman as well as being a tissue match. Experts said the study, published in the Lancet, was the latest example of the power of regenerative medicine

Human lungs in the lab. For the first time, scientists have created human lungs in a lab — an exciting step forward in regenerative medicine, but an advance that likely won’t help patients for many years.

The 2013 Nobel Prize in Physiology or Medicine: James E. Rothman, Randy W. Schekman and Thomas C. Südhof for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells

Miniature human liver grown in mice. Transplanting tiny 'liver buds' constructed from human stem cells restores liver function in mice, researchers have found. Although preliminary, the results offer a potential path towards developing treatments for the thousands of patients awaiting liver transplants every year. The liver buds, approximately 4 mm across, staved off death in mice with liver failure, the researchers report this week in Nature.

Regenerative Medicine Day at Skolkovo. February 14, 2013 declared as a “Regenerative medicine day in Russia” by Skolkovo Innovative Centre. The world well known scientists of the field made presentations in the Hypercube of Skolkovo.

3-5 December, 2012 the annual World Stem Cell Summit, the global stem cell and regenerative medicine community’s flagship event was held. It is the largest interdisciplinary, networking meeting of stem cell stakeholders, uniting the diverse regenerative medicine community. With the overarching purpose of fostering biomedical research, funding and investments targeting cures, the Summit is the single conference charting the future of this burgeoning field.

John B. Gurdon of the Gurdon Institute in Cambridge and Shinya Yamanaka of Kyoto University in Japan have won the 2012 Nobel Prize for Physiology or Medicine for finding that cells of an adult organism—once thought be terminally locked into their developed state—can start anew. The discoveries, awarded the prize by The Nobel Assembly at Karolinska Institute in Stockholm, have ignited research in areas ranging from cloning to cancer treatment.

3-rd Tissue Engineering and Regenerative Medicine Congress (5-8 September 2012, Vienna, Austria) brought together more than 3000 scientists all over the world represented different fields. Scientific program included about 300 oral presentations and 1500 posters.

The 3rd World Congress TERMIS «Tissue Engineering and Regenerative Medicine» will take place in Vienna in September 5-8, 2012. The TERMIS is the premier location for the international community of TERMIS members to present their research and interact with top researchers, clinicians, scientists, students and industry.

A òew Center of Regenerative Medicine, one of the biggest in Europe, was open in Edinburgh. The £54million building is the first large-scale, purpose-built facility of its kind in the UK.

A team, led by Prof Alexander Seifalian of the Department of Nanotechnology and Regenerative Medicine in University College, London, claims it's actually focusing on growing replacement organs and body parts to order, using a patient's own cells.

Regenerative medicine repairs mice from top to toe. Three studies published in April 2012 in Nature magazines show that introducing new cells into mice can replace diseased cells — whether hair, eye or heart — and help to restore the normal function of those cells. These proof-of-principle studies now have researchers setting their sights on clinical trials to see if the procedures could work in humans.

Engineering whole organs: closing in on a potential solution to the organ donor shortage?

Compaction enhances extracellular matrix content and mechanical properties of tissue engineered cartilaginous constructs

Hydrogel derived from decellularized ventricular extracellular matrix increases cardiomyocyte survival and preserves post-myocardial infarction

Biomechanical and angiogenic properties of tissue-engineered rat trachea using genipin cross-linked decellularized tissue

The Use of Human Sweat Gland–Derived Stem Cells for Enhancing Vascularization during Dermal Regeneration

Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses

2012 © Kuban State Medical University. The official website of the project "Investigating the molecular mechanisms and underlying pathways of regenerative medicine approaches the tissue-engineering and cell therapy of airways and lungs"