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Grant of the Government of the Russian Federation for the state support of scientific researches, which are conducted under the guidance of leading scientists in Russian educational institutions of higher professional education (agreement No. 11.G34.31.0065 dated October 19, 2011)

Regeneration of airways and lung

The official website of the project "Investigating the molecular mechanisms and underlying pathways of regenerative medicine approaches the tissue-engineering and cell therapy of airways and lungs"

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The Use of Human Sweat GlandDerived Stem Cells for Enhancing Vascularization during Dermal Regeneration

Stem cells derived from human sweat glands were isolated, characterized, seeded in collagen scaffolds, and engrafted in a mouse full skin defect model for dermal regeneration. Results - as Journal of Investigative Dermatology  reports - showed that these cells exhibit high proliferation rates and express stem cell and differentiation markers. Moreover, cells responded to angiogenic environments by increasing their migration (P<0.001) and proliferation (P<0.05) capacity and forming capillary-like structures. After seeding in the scaffolds, cells distributed homogeneously, interacting directly with the scaffold, and released bioactive molecules involved in angiogenesis, immune response, and tissue remodeling. As autologous sweat gland–derived stem cells are easy to obtain, exhibit a good proliferation capacity, and improve vascularization during dermal regeneration, there were  suggested to use them for dermal regeneration in future clinical settings.

http://www.nature.com/jid/journal/vaop/ncurrent/full/jid201231a.html?elq=b4a9aaedd1be498d978f99b7e0121931

2012 Kuban State Medical University. The official website of the project "Investigating the molecular mechanisms and underlying pathways of regenerative medicine approaches the tissue-engineering and cell therapy of airways and lungs"