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Grant of the Government of the Russian Federation for the state support of scientific researches, which are conducted under the guidance of leading scientists in Russian educational institutions of higher professional education (agreement No. 11.G34.31.0065 dated October 19, 2011)

Regeneration of airways and lung

The official website of the project "Investigating the molecular mechanisms and underlying pathways of regenerative medicine approaches the tissue-engineering and cell therapy of airways and lungs"

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Online questions to Professor Macchiarini

Alexander B. (Moscow)
Who first proposed the method of artificial (tissue-engineering) trachea? Does the implementation  of this idea belong to you?

 There have been several attempts to replace the trachea with artificial prosthesis in the 70’. By that time, no cells were seeded on the prostheses and the outcome was about a mortality rate of  percent due to infection, dislocation, granuloma formation, mediastinatis, etc.  We were the first group that combined all the classical components of tissue engineering organ and tissue replacements, namely the scaffolds, cells and bioreactor  in the preclinical and clinical scenario.

Gimat D. (Makhachkala)
What conditions do you consider to be "ideal" (i.e, the so-called "ideal model") for the cultivation of cells in the graft, and what conditions - the real (within the capabilities of existing technologies), and what - are implemented within your practice and work?

 Based on our previous studies, the ideal culture condition for a tubular structure like the trachea is a continuous rotation of the scaffold passing via  both, a gas and liquid phase; We developed this method together with the Technical University of Milano, Italy (Prof. Mantero and Drs. Asnaghi). It is very  important to combine the expertise and knowledge of both cellular biologists and engineers, and many  others
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2012 Kuban State Medical University. The official website of the project "Investigating the molecular mechanisms and underlying pathways of regenerative medicine approaches the tissue-engineering and cell therapy of airways and lungs"