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Grant of the Government of the Russian Federation for the state support of scientific researches, which are conducted under the guidance of leading scientists in Russian educational institutions of higher professional education (agreement No. 11.G34.31.0065 dated October 19, 2011)

Regeneration of airways and lung

The official website of the project "Investigating the molecular mechanisms and underlying pathways of regenerative medicine approaches the tissue-engineering and cell therapy of airways and lungs"

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First bioartificial stem-cell based laryngo-tracheal transplantation

The first bioartificial stem-cell based laryngo-tracheal transplantation was performed on June 19th at the Krasnodar Regional Hospital (Russia) by Paolo MACCHIARINI, professor of regenerative surgery at the Karolinska Institutet (Sweden, Stockholm), and collegues.

Prof. Maccharini led an international team including Prof. Vladimir PORHANOV, head of oncological and thoracic department of Kuban State Medical University (Russia), Nanofiber Solutions (Ohio, USA) who produced the nanocomposite laryngo-tracheal scaffold and Harvard Bioscience (Boston, USA) who produced a specifically designed bioreactor used to seed the scaffold with the patient´s own stem cells. The cells were grown on the scaffold inside the bioreactor for two days before transplantation to the patient. Because the cells used to regenerate the trachea were the patient’s own, there has been no rejection of the transplant and the patient is not taking immunosuppressive drugs. This is also the first patient entering a clinical trial on regenerative medicine replacement, and is supported by a Megagrant of the Government of the Russian Federation, designed to invite the leading scientists worldwide to Russian universities..

The patient, a 33 years old mother of one child from Saint-Petersburg suffered from a narrowing of the laryngo-tracheal junction for which she already had a failed previous surgery. Transplantation was the last resource for the patient to breath and speak normally and get a normal quality of life. Immediately after transplantation she was able to speak and breath normally, and has recovered completely.

This transplantation program is supported by a Megagrant of the Russian Government to develop technologies in the field of the regenerative medicine. The main aim is the evaluation of the molecular mechanisms and underlying pathways of tissue-engineering and cell therapy for regenerating airways and lung .

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Contacts:

Prof. Paolo Macchiarini

paolo.macchiarini@ki.se

+46 760503213

Karolinska Institutet

 

For press:

Elena Kokurina

longevity.foundation@gmail.com

+7 985 1395088

2012 Kuban State Medical University. The official website of the project "Investigating the molecular mechanisms and underlying pathways of regenerative medicine approaches the tissue-engineering and cell therapy of airways and lungs"